Human metallo-β-lactamase enzymes degrade penicillin
نویسندگان
چکیده
منابع مشابه
Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
β-Lactamases enable resistance to almost all β-lactam antibiotics. Pioneering work revealed that acyclic boronic acids can act as 'transition state analogue' inhibitors of nucleophilic serine enzymes, including serine-β-lactamases. Here we report biochemical and biophysical analyses revealing that cyclic boronates potently inhibit both nucleophilic serine and zinc-dependent β-lactamases by a me...
متن کاملNew Delhi Metallo-β-Lactamase, Ontario, Canada
To the Editor: The New Delhi metallo-β-lactamase (NDM-1) was fi rst characterized in 2009 from Kleb-siella pneumoniae and Escherichia coli isolated from a patient in Sweden who had received medical care in New Delhi, India (1). Further studies have shown broad dissemination of this β-lactamase gene (bla NDM-1) in India, Pakistan, Bangladesh, and the United Kingdom (2). Additional isolates have ...
متن کاملNew Delhi metallo-β-lactamase-1: detection and prevention.
1240 CMAJ, August 9, 2011, 183(11) © 2011 Canadian Medical Association or its licensors The advent of New Delhi metallo-β lactamase-1 (NDM-1) as a new mechanism of microbial resistance went mostly unmarked, despite it being plasmidmediated, highly transferable and able to confer resistance to most antibiotics (with the exceptions of colistin and tigecycline). However, after the Indian subcontin...
متن کاملEmergence of New Delhi Metallo-β-Lactamase, Austria
To the Editor: Extended-spectrum β-lactamase–producing Enter-obacteriaceae strains have emerged as a major public health problem throughout the world, particularly in India and Pakistan. The widespread use of carbapenems, the only agents reliably active against these bacteria, resulted in the emergence of a new resistance mechanism. New Delhi metallo-β-lactamase (NDM-1) was fi rst detected in a...
متن کاملOverview Metallo-β-lactamase inhibitors: Promise for the future?
Carbapenem resistance continues to erode the effectiveness of antibiotics such as imipenem and meropenem in the clinic. Resistance mechanisms can include interplay between porin loss (membrane permeability), mutation of penicillin binding proteins necessary for cell division, and expression of class A, B and D β-lactamases. Bacterial resistance to β-lactams such as penicillin or amoxicillin has...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-48723-y